Search results for " IL-17"

showing 5 items of 5 documents

Intestinal dysbiosis and innate immune responses in axial spondyloarthritis

2016

Purpose of review Inflammatory innate and adaptive immune cell responses to commensal bacteria underlie the pathogenesis of human chronic inflammatory diseases. Intestinal dysbiosis has been described in patients with spondyloarthritis (SpA) and seems to be correlated with histologic and immunologic alterations. Purpose of this review is to discuss the relationship occurring between intestinal dysbiosis and innate immune responses in patients with axial SpA. Recent findings Intestinal dysbiosis and differential activation of intestinal immune responses in patients with SpA have been demonstrated. Furthermore, innate cells that appear to be involved in the pathogenesis of SpA may control int…

0301 basic medicinePathogenesis03 medical and health sciences0302 clinical medicineImmune systemRheumatologyImmunityIL-23dysbiosis; gut inflammation; IL-17; IL-23; IL-9; innate lymphoid cells; spondyloarthritis; RheumatologySpondylarthritisInterleukin 23MedicineHumansspondyloarthriti030203 arthritis & rheumatologyInnate immune systemBacteriabusiness.industrydysbiosiInnate lymphoid cellmedicine.diseaseIL-9Immunity InnateGastrointestinal MicrobiomeIntestinesIL-17030104 developmental biologyImmunologyinnate lymphoid cellDysbiosisInterleukin 17gut inflammationbusinessDysbiosis
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Invariant NKT cells are expanded in peripheral blood but are undetectable in salivary glands of patients with primary Sjögren's syndrome

2016

OBJECTIVES: Invariant NKT (iNKT) cells play a role in regulating the function of autoreactive B cells before their entry into germinal centres. Absence and/or reduction of iNKT cells have been demonstrated in patients with systemic lupus erythematosus (SLE) together with an increase of autoreactive B cell activity. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease in which lymphocyte infiltration and organisation in lymphoid structures of inflamed salivary glands occurs. The aim of the study was to investigate the percentage and function of iNKT in the salivary glands and peripheral blood of patients with pSS. METHODS: Minor salivary gland biopsies were obtained from patient…

BiopsyReceptors Antigen T-CellFluorescent Antibody TechniqueEnzyme-Linked Immunosorbent AssayCell CommunicationLymphocyte ActivationReal-Time Polymerase Chain ReactionSalivary GlandsInterferon-gammastomatognathic systemHumansLymphocyte CountCells CulturedCell ProliferationB-LymphocytesInterleukin-17Flow CytometryCoculture TechniquesSettore MED/16 - Reumatologiastomatognathic diseasesIL-17Sjogren's SyndromeAntibodies AntinuclearCase-Control StudiesAntibody FormationNatural Killer T-CellsSjögren's syndromeNKT cellNKT cells Sjögren's syndrome IL-17
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Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma

2015

Interleukin (IL)-17A belongs to IL-17 superfamily and binds the heterodimeric IL-17 receptor (R)(IL-17RA/IL-17RC). IL-17A promotes germinal center (GC) formation in mouse models of autoimmune or infectious diseases, but the role of IL-17A/IL-17AR complex in human neoplastic GC is unknown. In this study, we investigated expression and function of IL-17A/IL-17AR in the microenvironments of 44 B cell non-Hodgkin lymphomas (B-NHL) of GC origin (15 follicular lymphomas, 17 diffuse large B cells lymphomas and 12 Burkitt lymphomas) and 12 human tonsil GC. Furthermore, we investigated the role of IL-17A in two in vivo models of GC B cell lymphoma, generated by s.c. injection of SU-DHL-4 and OCI-Ly8…

Cell typeImmunologySettore MED/08 - Anatomia PatologicaangiogenesisB non-Hodgkin lymphomahemic and lymphatic diseasesmedicineIL-17AImmunology and Allergytumor immunologyCXCL13B-cell lymphomaangiogenesis; B non-Hodgkin lymphoma; GC B cells; IL-17A; IL-17A receptor; tumor immunology; Immunology and Allergy; Oncology; ImmunologyB cellOriginal ResearchSevere combined immunodeficiencybusiness.industryIL-17A receptorGerminal centerInterleukinangiogenesimedicine.diseaseMolecular biologyGC B cellmedicine.anatomical_structureOncologyCell cultureImmunologyGC B cellsbusiness
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γδ T cell-based anticancer immunotherapy: Progress and possibilities

2015

Cytotoxicity Immunologicmedicine.medical_treatmentT cellT-LymphocytesImmunologyImmunotherapy AdoptiveInterferon-gammaNeoplasmsTumor MicroenvironmentImmunology and AllergyMedicineAnimalsHumansSettore MED/04 - Patologia GeneraleTumor microenvironmentTumor-infiltrating lymphocytesbusiness.industryInterleukin-17Neoplasms therapyReceptors Antigen T-Cell gamma-deltaImmunotherapymedicine.anatomical_structureγδ T cells • cancer • IFN-γ • IL-17 • immunotherapy • PD-1 • tumor-infiltrating lymphocytesOncologyImmunologySettore MED/46 - Scienze Tecniche Di Medicina Di Laboratoriobusiness
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Differentiation, phenotype, and function of interleukin-17-producing human V{gamma}9V{delta}2 T cells

2011

gamma delta T cells IL-17
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